Senior Scientist

Reports To: Director, Head of Bioanalytics

Classification: Full time employee or contract

Job Summary

We are seeking a highly motivated scientist with a background in molecular and cellular biology and/or biochemistry to be a part of our passionate and interdisciplinary team. The successful candidate will have extensive hands-on experience in bio-analytics, biomarker and translational research approaches and a flexible and strong drive for embracing a fast-paced, science-driven environment. This is a unique opportunity to work at a nimble, forward-thinking startup and help build the foundation for a new generation of RNAi therapies.

This position reports to the Director of Bio-analytics and requires on location work in our South San Francisco office.

The pay range for this position at commencement of employment is expected to be between $125,000 – $150,000 per year depending on experience. However, base pay offered may vary depending on other multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including equity in the Company, a discretionary annual bonus, in addition to a full range of healthcare, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave. Details of participation in these benefit plans will be provided if a candidate receives an offer of employment.If hired, the employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Interested applicants should send a resume and cover letter to careers@switchthera.com

Responsibilities

• The candidate will be required to lead cell and molecular biology workflows by applying biochemistry and biology skills, such as nucleic acid preparation, RNA isolation, tissue homogenate preparation, protein assays, or cell culture, to a variety of biology and bioanalytical experiments.
• Responsible for hands-on laboratory-based research for sample/tissue processing and reliable Pharmacokinetic (PK) and Pharmacodynamic (PD) data generation using cutting edge technologies such as MSD, QuantiGene, qPCR, AlphaLISA or TR-FRET.
• Will perform tissue culture work.
• Must be a team player and will work closely with other team members.
• Management of inventory systems and liquid handling systems.
• Will communicate data to the manager and present it in team/group meetings.
• Maintains lab notebooks, ELN and efficiently generate, process and report data accurately to team members and managers.

Required Qualifications

• PhD degree in biology, pharmacology, or related field is required.
• At least 3 years of experience in industry is required.
• Experience in molecular and cell biology is required.
• Must have excellent written, verbal, and interpersonal communication skills.
• Must have attention to detail, planning, and organizational skills.

About Switch

Switch Therapeutics is an emerging biotechnology company that is developing RNAi therapies stemming from transformative technologies invented at Caltech, City of Hope, and Harvard Medical School.

The company’s conditionally activated siRNA (CASi) platform integrates RNA nanotechnology with RNA medicinal chemistry to create siRNA pro-drugs that can activate or suppress their own drug activities based on the presence or absence of disease indicating RNA markers in mammalian cells. This gives CASi based drugs the ability to target specific cells responsible for disease while sparing healthy cells from drug activity.

Since its founding in Q3 2020, Switch has made significant progress in optimizing its technology for therapeutic applications and has generated highly compelling in vivo validation data demonstrating distribution, potency, and duration of effect that support development for important disease indications.

Interested applicants should send a resume and cover letter to careers@switchthera.com.